Investigation of biological efficacy assessment of cobalt-doped cerium oxide nanocomposites against pathogenic bacteria, fungi, and lung cancer cells

Abstract

This paper presents the fabrication of cobalt doped-cerium oxide nanocomposites (Co/CeO2 NCs) by solid combustion method. Synthesized cobalt doped CeO2 nanocomposites and pure CeO2 were confirmed by UV–Visible spectrophotometer, Fourier transform infrared spectrometer (FTIR), X-ray diffraction study (XRD), BET analysis and transmission electron microscope coupled with energy dispersive spectroscopy (TEM-EDS). The bandgap energies of CeO2, 0.25, 0.50 and 0.75%Co/CeO2 NCs were 3.02, 2.98, 2.81 and 2.80 eV, respectively. The 50 % inhibitory concentration (IC50) values of CeO2, 0.25, 0.50, and 0.75 % of Co-doped CeO2 were 57.02, 38.65, 35.33 and 39.87 μg/mL, respectively. The oxidation state of Cobalt and Cerium was confirmed by X-ray photoelectron spectrum. The Co/CeO2 NCs exhibited a zone of inhibition against bacteria and fungi. Thus, Co/CeO2 NCs can be used as a biomaterial for controlling pathogenic bacteria, fungi and lung cancer cell lines.