Abstract
Alzheimer’s disease is the most common form of dementia with polygenic disposition occurring within various populations. A series of molecular studies indicated that there are number of genes linked to late onset Alzheimer’s disease (AD). In the current study, we examined the contribution of B2-AR (Gly16, Arg), TLR2 (-196TO-174del), PICALM (rs3851179) and BDNF (rs6265) alleles and genotypes, and their relevance in response to Rivastigmine in 150 Iranian AD patients and 150 controls.
Highlights
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with polygenic and multifactorial inheritance, determined by progressive loss of memory and other cognitive functions
The initial data analysis did not show any significant association between the B-adrenergic receptor (B2-AR) alleles or genotypes with total AD patients as compared with the control group (Table 1)
Further analysis revealed that the B2-AR G allele is more frequent in the familial Alzheimer’s disease (FAD) patients (75%) compared to the controls (61.6%) (Pc=0.02), yielding an increased absolute risk of 2.7% (PcPPV=2.7, RR=1.21, 95%CL=1.06-3.29) and On the other hand, the frequency of B2-AR A allele was significantly higher in the control group (38.3%) than in the FAD patients (25%) (Pc=0.02, RR=0.65, 95%CL = 0.30-0.94)
Summary
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with polygenic and multifactorial inheritance, determined by progressive loss of memory and other cognitive functions.
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