Abstract
BackgroundThe goal of this study was to evaluate the relationship between maternal 25-OH Vitamin D serum levels and neonatal early-onset sepsis in newborns by the effective factors.MethodsA case-control study was done and 64 neonates hospitalized in Akbar Abadi Hospital (Tehran- Iran; 2016) and their mothers were enrolled. The case group consisted of 32 NICU term hospitalized neonates due to neonatal early-onset sepsis. Thirty-two term newborns that referred to hospital for rule out hyperbilirubinemia during the first 72 h of life were also considered as the control.ResultsSixty- four mothers with mean age 28.76 ± 6.60 years and mean gestational age 39.64 ± 1.62 weeks entered the study. There was a significant correlation between sepsis and older age of mothers and low Apgar score (P-value = 0.02, 0.01 respectively). The maternal vitamin D serum level was reversely correlated with neonatal sepsis occurrence (P-value = 0.03). There was a significant correlation between maternal vitamin D supplement intake during pregnancy and lower risk for neonatal sepsis (P-value = 0.003).ConclusionThe level of maternal serum Vitamin D was inversely correlated with neonatal sepsis occurrence and intake of vitamin D supplement during pregnancy could decrease the risk of early neonatal sepsis.
Highlights
The goal of this study was to evaluate the relationship between maternal 25-OH Vitamin D serum levels and neonatal early-onset sepsis in newborns by the effective factors
Recent studies have indicated a correlation between maternal serum vitamin D status and health consequences for neonates, it has been indicated that maternal 25OHD is markedly associated with offspring birth weight, where vitamin D controlling gestational age plays a key role in mediating the effect of 25 (OH) D on birth weight
The mean maternal serum vitamin D was determined as 25.72 ± 12.37 (Min: 2, Max: 51.8), (Table 1)
Summary
The goal of this study was to evaluate the relationship between maternal 25-OH Vitamin D serum levels and neonatal early-onset sepsis in newborns by the effective factors. Neonatal early-onset sepsis (NEOS) defines as systemic bacteremia with positive blood or cerebrospinal fluid culture in the first 7 days of neonate’s life. It is a serious complication with relatively low incidence (0.5–1.2 cases per 1,000 live births) and high morbidity/mortality rates [1,2,3]. Increasing evidence from a Saboute et al Lipids in Health and Disease (2019) 18:153 meta-analysis of randomized controlled trials has helped to elucidate the role of D supplementation on maternal and neonatal results, where at pregnancy time the vitamin D supplementation appear to be related to a higher circulating 25(OH) D levels, birth length and birth weight. There is close and deep relationship between maternal and fetal vitamin D [11]
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