Abstract
Investigation of antimicrobial effect of crude extract and three sub-fractions of Platychaete aucheri (Boiss.) Boiss against five standard microbial strains and clinical Escherichia coli isolates
Highlights
Today due to increase of bacterial resistance to chemical drugs and their potential adverse effects, searching on new medicinal plants is rising (Hakemivala et al, 2014)
The present study was aimed to evaluate the antimicrobial activity of crude methanolic extract and three sub-fractions of the flowering aerial parts of Platychaete aucheri against some gram-positive and gram-negative standard bacteria, Candida albicans and clinical Escherichia coli isolated from urinary tract infections (UTIs) and burn wounds
Experimental: Total methanolic extract of P.aucheri was prepared by maceration method.Further chloroform, petroleum ether and aqueous fractions were obtained by using liquid-liquid extraction method
Summary
Today due to increase of bacterial resistance to chemical drugs and their potential adverse effects, searching on new medicinal plants is rising (Hakemivala et al, 2014). Platychaete aucher (Boiss.) Boiss,is one of the Asteraceae family and has limited dispersion in south of Iran (Mozaffarian, 2006). The genus platychaete comprises 5 herbaceous perennial species (Zarrin et al, 2010) This plant has beautiful yellow flowers and it can grow up to a height of about 60 cm. Fumes obtained from burning used as an adjuvant therapy to treat measles and as an agent for repelling insects This plant is used as a fragrance in handmade soaps (Asgarpanah et al, 2016). Emerge of drug resistant isolates are seen worldwide including in Iran. In such situations, treatment by carbapenems such as imipenem is recommended (Abdi et al, 2014). Due to the wide spread use of P.aucheri in Iranian traditional medicine as an antimicrobial agent, we were prompted to evaluate the antimicrobial activity against two gram-positive, two gram-negative standard bacteria, standard C. albicans and clinical E. coli strains isolated from wounds of burnt patients and from urine of patients suffering from UTIs
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