Abstract
Introduction: Acne vulgaris is a common skin disorder characterized by non-inflammatory and inflammatory lesions. The current therapy has severe side effects, therefore needs alternative therapy to treat such disease. Objective: This study has been taken to investigate in vitro anti-acne activity of Azardirachta indica Linn., Glycyrrhiza glabra Linn., and Ocimum basilicum Linn.extract and its oil. Materials and Methods: In this study, different extracts and its oil were evaluated against the Propionibacterium acne, Staphylococcus epidermidis by agar well diffusion method. Tetracycline disc and dalacinTM (1%clindamycin phosphate solution) were taken as positive control. Result and Conclusion: Ocimum basilicum extract showed significant activity but the anti-acne activity shown by its oil is comparatively greater than Ocimum basilicum extract. Azardirachta indica ethanol fraction showed greater activity as compared to Azadirachta indica ethanol extract, and the Azardirachta indica chloroform fraction, pet ether fraction and ethyl acetate fraction showed moderate action. Hence from the study it can be concluded that basil oil, ethanolic extract of neem can be used for the treatment of acne vulgaris.
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