INVESTIGATION OF ANTI-CANCER PROPERTIES OF COMPONENTS EXTRACTED FROM POLAR MICROALGAE

Abstract

Cancer is irregular cell division that can be inherited or occur under environmental factors. Due to mutations in DNA, damage occurs in the cell division mechanism and cells divide uncontrollably [1]. Natural compounds are widely preferred in the treatment of cancer, which is the second leading cause of death. Microalgae have a great role in cancer treatment because they have rich bioactive components and high efficiency [2,3]. Microalgal biomass has many uses in a wide variety of fields, thanks to its potential for rich bioactive compounds and its ability to be used as a sustainable bio- product source. It provides benefits [3]. Therefore, research on microalgae is increasing as biotechnology advances. Bioactive compounds derived from microalgae are a natural, safe, and renewable resource and are research subjects for nutraceutical and pharmaceutical applications due to their potential therapeutic properties [4]. These bio-actives also have drug delivery, wound healing, and antioxidant, anti-oxidant, anti-inflammatory, neuroprotective, and anti-carcinogenic properties [5]. There is a lot of research done on microalgae. And these studies continue to increase. This study aims to determine the content of microalgae obtained from the polar regions and to investigate their anti-cancer properties, thus adding new information to the knowledge in the literature. Microalgae has been proven to have anti-cancer properties due to its bioactive properties. While microalgae exhibit natural killer cell activity against cancer cells, they also activate the immune system. There are no studies in the literature regarding the anticancer effects of polar microalgae. This project aims to extract the contents of various polar algae species and analyze these contents, then examine their anticancer properties through cancer lines and offer an alternative way to treat this disease. After investigating the properties of the produced polar microalgae, the substance obtained through extraction will be applied to cancer cells to study its anticancer activity. The primary field contribution of this project is to examine the anti-cancer activity of polar microalgae in various types of cancer and to pave the way for the production of polar algae-based biotechnological drugs. Therefore, one of our main goals is to fill the gaps in the literature and pioneer other studies. Keywords: Polar Microalgae, Biotechnology, Neuroprotective, Anti-inflammatory, Anti-carcinogenic.