Abstract
Abstract Alkylation of DNA gives rise to adducts, not only at the bases, but also at the phosphate groups giving phosphotriesters1–3. 2-Hydroxy-alkylation of phosphodiester functions in DNA causes considerable strand breakage already in neutral solution4. This effect has been suggested to be involved in the higher genotoxicity of 2-hydroxyalkylating agents as compared to, for instance, the corresponding methoxy compounds5.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
