Abstract
The functions and transformation mechanisms of nucleic acids in their various states are of great importance in physiology and pathology. Based on the Landau model, this study reveals the mechanism of the existence of chirality and the transformation rules between different chiral conformations by studying the Duffing oscillation response of the local gauge potential on the DNA chain. The research results show that normal chiral DNA and DNA configuration transition behaviors exhibit regular nonlinear periodic oscillations. Moreover, the gauge potential value approaches zero at the B-Z junction site, which may add a criterion for detecting Z-forming sites. In addition, external force and damping play a key role in the chiral gauge potential of nucleic acids, and they can influence, regulate and even control the configuration transition of nucleic acids. Finally, we verified the rationality of our theory by combining x-ray crystal diffraction data of multiple configurations of DNA. This study provides new insights into the behavior and function of chiral DNA in organisms, and provides new possibilities for regulating DNA conformational transition in the future.
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