Abstract

Investigation into MoTe2 Based Dielectric Modulated AMFET Biosensor for Label-Free Detection of DNA Including Electric Variational Effects

Highlights

  • To serve a larger spectrum of humanity, biosensors have been evolved and enabled for label-free detection in the arena of agriculture, medicine, ecological surveys, food industry, etc. [1, 2].The reason behind the popularity of label-free biosensors is its immediate response capability for bio-analyte identification without complex probe arrangements

  • Due to limitations of Silicon, Transition metal dichalcogenides (TMD) based biosensors are popular in the recent times

  • We have proposed a Molybdenum telluride (MoTe2) based Accumulation Mode Field Effect Transistor (AMFET) for possible dielectric modulated biosensing application

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Summary

Introduction

To serve a larger spectrum of humanity, biosensors have been evolved and enabled for label-free detection in the arena of agriculture, medicine, ecological surveys, food industry, etc. [1, 2].The reason behind the popularity of label-free biosensors is its immediate response capability for bio-analyte identification without complex probe arrangements. Changes in electrical properties quantify the sensitivity for label-free detection for both neutral & charged molecules viz. At biosensor cavity thickness touching sub-10 nm regime, several research works are focusing on FinFET & nanowire FET for detection of DNA, Proteins, viruses, etc. After isolation of graphene in 2004, research works in ultra-scaled DMFET biosensor has been flourishing based on TMD (MoS2, MoSe2, WS2, WSe2 etc.) material. Hwang et al has reported crumpled graphene 2D material-based FET biosensor with ultrasensitive detection of DNA and RNA molecules with significantly low limit of detection (LOD) [16]. As these lead to significant performance degradation, the minimum detection limit becomes a vital performance parameter in addition to sensitivity in the scaled regime In this manuscript, we have proposed a MoTe2 based Accumulation Mode Field Effect Transistor (AMFET) for biosensing application. The study has been conducted on both device and circuit levels

Device Structure And Simulation Methodology
Benchmarking
Results And Discussion
DNA Detection without considering DNA-Electrode Interaction
DNA Orientation Effect and Implementation Methodology
DC Simulations
Transient Simulations
Impact of Back-Gate Bias
Variation of Biosensor performance for irregular orientation of DNA
Conclusion
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