Investigation into miRNA profile in patient groups with and without ST elevation

Abstract

Abstract Objectives Because acute myocardial infarction (AMI) may occur suddenly and cannot be predicted, it is critical to identify early diagnosis markers. In recent years, in addition to the developing diagnostic methods, other markers that may be related to the diagnosis of AMI are miRNA molecules. The specificity of miRNAs involved in the pathogenesis of atherosclerosis and regulation of cardiac functions has been shown. The present study aimed to investigate the changes in miRNA expression levels in MI patients with ST-elevation (STEMI) and without ST elevation (NSTEMI). Methods In this study, 25 patients with STEMI, 25 with NSTEMI, and 20 healthy participants were included. Expression analysis of miRNAs isolated from the plasma of individuals was performed using high-throughput real-time PCR. Results Compared with the control group, miR-221-3p and miR-30d-5p were downregulated, while miR-25-3p, miR-92a-3p, miR-34a-5p and miR-150 upregulated in the patient group with NSTEMI; miR-221-3p, miR-25-3p, miR-30d-5p and miR-92a-3p were downregulated while miR-208a-3p was upregulated in patients with STEMI (p>0.05). Conclusions In conclusion, miRNAs may be an early biomarker for diagnosing AMI; however, further and larger studies are needed.