Abstract
Bacterial infections remain the leading killer worldwide which is worsened by the continuous emergence of antibiotic resistance. In particular, antibiotic resistant Gram-negative bacteria are prevalent and extremely difficult to treat. Therefore, rejuvenating the therapeutic potentials of existing antibiotics represents an attractive novel strategy. Antimicrobial peptides have been of great focus recently. Newly derived synthetic lipopeptides have been shown to exhibit antimicrobial activity against bacteria and fungi.
Highlights
Bacterial infections remain the leading killer worldwide which is worsened by the continuous emergence of antibiotic resistance
In this study, we investigated the ability of an antimicrobial peptide, PA-KKkK, to enhance the potency of currently used antibiotics against antibiotic-resistant clinical isolates of Escherichia coli and a NDM-1 producing strain
NDM-1 producing strain was extremely resistant to all antibiotics tested
Summary
Bacterial infections remain the leading killer worldwide which is worsened by the continuous emergence of antibiotic resistance. Antibiotic resistant Gramnegative bacteria are prevalent and extremely difficult to treat. Rejuvenating the therapeutic potentials of existing antibiotics represents an attractive novel strategy. Antimicrobial peptides have been of great focus recently. Derived synthetic lipopeptides have been shown to exhibit antimicrobial activity against bacteria and fungi
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