Abstract
We have conducted an investigation for the influence of different magnesium sulfate doses on the content of calcium and chloride in blood serum of rats of both genders. As the result of the study, we have established that peroral administration of magnesium sulfate at dose 1.7 g/kg leads to the significant decrease of chlorides content in blood serum of male rats, concerning the control group of animals, and at dose 5 g/kg to the decrease of concentration, chloride as well as calcium in rats of both genders.
Highlights
At present, obstipation conditions are frequently encountered
The control group of rats was given a clean water in the same volume
On the 8th day all experimental animals were sacrificed by decapitation under chloral hydrate anesthesia (350 mg/kg) and took a blood sample for further blood serum extraction, and determination of the content of calcium and chloride
Summary
According to some foreign authors chronic constipation is encountered in 1.9–27% of patients aged under 65 [3]. People after 65 years have this condition in 12.5–30% of cases [5]. Of all patients with this kind of disorders only 34% call for medical help [6]. As the result the frequency of uncontrollable, self-treatment with depletive agents increase, which often leads to undesirable side effects [4].
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