Investigation and analysisof Keshan disease status and associated factors in Shaanxi Province in 2006

Abstract

：Objective To know theprevalence tendency of Keshan disease(KSD) under control after 10 years in ShaanxiProvince, the factors that causes or relative to the disease, to provide scientificreference for disease's prevention and control. Methods Through stratified clustersampling, based on the severity of KSD in endemic area of Shaanxi Province, 12 villagesfrom 6 counties were randomly selected as investigation points in 2006. The people olderthan 3 year-old were chosen to do clinical check up and electrocardiogram tracing. Amongthem, suspicious or abnormal cases were asked to take chest X-ray and cardiac ultrasound.Maize and rice, hair and whole blood were randomly collected to test the selenium content,the activity of Glutathione peroxidase (GSH-Px). Results The total detection rate ofpotential or chronic KSD was 2.44%(139/5694), the detection rate of abnormal ECG was 9.19%(523/5692), the detection rate of cardiac enlargement from chest X-ray and cardiacultrasound were 45.6%(72/158) and 34.5%(59/171) respectively. The average content ofselenium in staple foods(wheat and corn) were[(0.045±0.036), (0.035±0.025)mg/kg,respectively]. The level of hair selenium in patients and healthy people were [(0.376±0.091),(0.384±0.077)mg/kg, respectively], with non-significant different (u=0.77, P>0.05).There were significant differences in whole blood selenium of patients, healthy people inKSD areas and healthy people in non-KSD areas[(0.071±0.017), (0.077±0.017), (0.090±0.016)mg/L,respectively; F=4.55, P<0.05), the whole blood selenium in patients lower than inhealthy people in KSD areas (P<0.05), in healthy people in KSD areas lower than innon-KSD areas (P<0.05). Conclusions After the KSD condition being controlled, thesituation in Shaanxi Province has become stable and exhibited a decreasing tendency. Theselenium level of both internal and external environment in the endemic area increasedsignificantly, that is the main factors of controlling disease.