Investigation and analysis on antibiotics adverse drug reaction reports in our hospital, 2010-2012

Abstract

Objective To investigate and analyze the adverse reaction of antibiotic use cases in recent years,summarizing adverse reaction involving the heating organs and different kinds of antibiotics with adverse reaction in our hospital.Methods From 2010 to 2012,among patients using antibiotics,we selected 130 cases with adverse reactions,every year the number of cases showing adverse reactions was observed,using antibiotic occurrence trend and adverse reaction of antibiotics in the organs and tissues.Results The adverse reaction incidence of antibiotics was increasing year by year in our hospital,which had risen from 20.1％ in 2010 to 40.1％ in 2012; the main drugs causing adverse reaction was cephalosporin antibiotics,the main involving organs included the skin,nervous system and cardiovascular system,the skin involving adverse reaction was the most,occupying the proportion of 29.2％,with all statistical difference showing in all data,P ＜ 0.05.Conclusion The principle of medication needs to be strictly followed during antibiotics use.Abuse of antibiotics should be prohibited,the combination therapy,which can reduce adverse reaction and improve the curative effect,should be advocated. Key words: Antibiotics; Adverse reaction; Investigation and analysis