Abstract
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Highlights
Anticholinergic medications are useful for the management of primary axillary hyperhidrosis (AHH)
Binding studies at human muscarinic receptors (M1–M4) and guinea-pig ileum assays have found Sofpironium bromide (SB) to have potency close to glycopyrrolate with a shorter duration of action.[2]
In a separate maximum-use pharmacokinetic (PK) study of SB in human subjects with AHH, 3fold supratherapeutic application to the axillae, thighs, and palms had no meaningful impact on systemic exposure compared with the intended therapeutic dose.[5]
Summary
Anticholinergic medications are useful for the management of primary axillary hyperhidrosis (AHH). Due to inhibition of cholinergic receptors in tissues other than the targeted sweat glands, the use of both oral and topical anticholinergics for the treatment of AHH often results in systemic side effects, such as dry mouth, blurred vision, mydriasis, and urinary hesitation. Sofpironium bromide (SB) is a novel, quaternary ammonium, anticholinergic drug that is a retrometabolically designed structural analogue of glycopyrrolate
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