Investigating the Underlying Mechanisms of Circular RNAs and Their Application in Clinical Research of Cervical Cancer.

Jian Liu,Tianmin Xu,He Zhu,Li Fu

doi:10.3389/fgene.2021.653051

Jian Liu, Tianmin Xu + Show 2 more

Open Access

https://doi.org/10.3389/fgene.2021.653051

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Abstract

Circular RNAs (circRNAs) are non-coding RNA molecules, and these are differentially expressed in various diseases, including cancer, suggesting that circRNAs can regulate certain diseases. CircRNAs can act as miRNAs sponges, RNA-binding protein (RBP) sponges, and translation regulators, and they can become an important part of the regulation of gene expression. Furthermore, because of their biomedical features in body fluids, such as high abundance, conservation, and stability, circRNAs are seen as potential biomarkers for various cancers. Cervical cancer (CC) is one of the main causes of cancer-related death in women, and there have been a large number of studies that analyze circRNAs as a new object to be evaluated in CC. Therefore, this review, by understanding the role of circRNAs in CC, may create innovative strategies in the future clinical diagnosis, treatment, and prognosis of CC and promote the development of personalized and highly accurate cancer therapy.

Highlights

Circular RNAs are a special class of non-coding RNA molecules that do not have a 5 terminus cap and a 3 terminus poly (A) tail
Owing to trans-shear, circular RNA (circRNA) is abundant in the cytoplasm of eukaryotic cells, and its localization in the cytoplasm is a sufficient and necessary condition to study the mechanism of miRNA sponge
Small numbers of intron-derived circRNAs are noted in nucleic acids and have certain tissue, timing, and disease specificities, and they are suitable for molecular markers (Zhang Z. et al, 2018)

Summary

Introduction

Circular RNAs (circRNAs) are a special class of non-coding RNA molecules that do not have a 5 terminus cap and a 3 terminus poly (A) tail. Hsa_circ_CSPP1 can regulate the proliferation and migration of CC cells through the miR-361-5p/ITGB1 axis, which is a part of the PI3K/AKT pathway. In SiHa and CaSki cells, the low expression level of circ-0745 decreased cell proliferation, invasion, and migration in vitro and reduced the tumor size in vivo.

Results

Conclusion