Abstract
SLC7 transporters are a family of membrane proteins from the amino acid polyamine cation (APC) superfamily, which control the relative concentration of amino acids inside and outside of the cell. Recent structural work (Yan, R. et al. 2019, Lee, Y. et al. 2019) has yielded structures of human SLC7 members with cholesterol densities. Given that several APC homologues (SLC7,36,38) are known to traffic between the differing environments of the plasma membrane, lysosome and the Golgi apparatus, we are investigating human SLC7 structures to analyse the role of lipids on the structural dynamics of these transporters.
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