Abstract
SLC7 transporters are a family of membrane proteins from the amino acid polyamine cation (APC) superfamily, which control the relative concentration of amino acids inside and outside of the cell. Recent structural work (Yan, R. et al. 2019, Lee, Y. et al. 2019) has yielded structures of human SLC7 members with cholesterol densities. Given that several APC homologues (SLC7,36,38) are known to traffic between the differing environments of the plasma membrane, lysosome and the Golgi apparatus, we are investigating human SLC7 structures to analyse the role of lipids on the structural dynamics of these transporters.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
