Investigating The Relationship Between The Mean Heart Doses Received In Left Breast Cancer Radiation Therapy With Pro-BNP And Troponin Values And Left Ventricular Systolic Function Based On Left Ventricle Ejection Fraction (LVEF) And Global Longitudinal Strain (GLS) Values In Echocardiography

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Abstract BACKGROUND: The purpose of this study is to investigate the relationship between the mean heart dose received in left breast cancer radiation therapy and cardiac injury as measured by Pro-BNP and Troponin laboratory levels and left ventricular systolic function, as measured by LVEF and GLS levels in echocardiography. METHOD: This research was carried out at Omid Hospital, Isfahan City, Iran, using the before and after intervention study and single-arm approach on a population of patients diagnosed with cancer of the left breast who received radiation therapy for the left breast between 2021- 2022. Troponin, Pro-BNP, GLS, and LVEF were investigated before and after intervention. The data was analyzed using the t-test and the Mann-Whitney U test. Ultimately, it was examined using version 22 of the SPSS program. RESULTS: This study showed a statistically significant difference in pro-BNP before and after the intervention (P<0.001). Also, we investigated the relationship between the mean heart dose, mean LAD dose, mean LV dose, radiotherapy protocol, and V25 index with the changes of Troponin, Pro-BNP, GLS, and LVEF, and we observed no statistically significant relationship between them (P>0.05). CONCLUSION: Left breast radiation therapy does not affect cardiac factors like LVEF and troponin in the short term. Also, we observed Pro-BNP meaningful changes and the effect of V25 on GLS after the radiation. Studies with a larger sample size and a longer follow-up period are suggested.