Investigating the predictive effect of amplitude integrated electroencephalography on prognosis of patients with high grade aneurysmal subarachnoid hemorrhage

Abstract

Objective To investigate the clinical value of amplitude-integrated electroencephalography in predicting the prognosis of patients with high grade aneurysmal subarachnoid hemorrhage. Methods Prospectively collected amplitude-enhanced EEG and clinical data of 23 patients with high-grade aSAH who underwent neurosurgery from the First Affiliated Hospital of Fujian Medical University from December 2016 to February 2018. The obtained aEEG was divided into aEEG normal group and aEEG abnormal group, and the prognosis of patients was evaluated according to the modified Rankin scale (mRS) scores of patients who were followed up for 3 months after discharge. The aEEG classification and prognosis were statistically analyzed. Results Of the 23 patients, 6 patients in the aEEG normal amplitude group had a good prognosis; 17 patients with aEEG abnormal amplitude group, including 3 patients with good prognosis and 14 patients with poor prognosis. Abnormal amplitude was 17 cases (9 of which were non-sustained normal amplitude group, 5 low voltage group, and 3 horizontal trend group). Three patients in the horizontal trend group died. The prognosis of aEEG was worse than normal, and the difference was statistically significant (P=0.001). Conclusion AEEG monitoring of abnormal amplitude after high-grade aSAH surgery can be used as a predictor of poor prognosis, amplitude integrated electroencephalogram showed a horizontal trend changes suggest a serious adverse prognosis. Key words: Amplitude integrated electroencephalography; High grade aneurysm subarachnoid hemorrhage; Modified Rankin scale