Abstract
BackgroundDanhong injection (DHI), which is one of the most well-known Traditional Chinese Medicine (TCM) injections, widely used to treat unstable angina (UA). However, its underlying pharmacological mechanisms need to be further clarified.MethodsIn the present study, network pharmacology was adopted. Firstly, the relative compounds were obtained by a wide-scaled literatures-mining and potential targets of these compounds by target fishing were collected. Then, we built the UA target database by DisGeNET, DigSee, TTD, OMIM. Based on data, protein-protein interaction (PPI) analysis, GO and KEGG pathway enrichment analysis were performed and screen the hub targets by topology. Furthermore, evaluation of the binding potential of key targets and compounds through molecular docking.ResultsThe results showed that 12 ingredients of DHI and 27 putative known therapeutic targets were picked out. By systematic analysis, identified 4 hub targets (TNF, TLR4, NFKB1 and SERPINE1) mainly involved in the complex treating effects associated with coagulation and hemostasis, cell membrane region, platelet alpha granule, NF-kappa B signaling pathway and TNF signaling pathway.ConclusionThe results of this study preliminarily explained the potential targets and signaling pathways of DHI in the treatment of UA, which may help to laid a good foundation for experimental research and further clinical application.
Highlights
Danhong injection (DHI), which is one of the most well-known Traditional Chinese Medicine (TCM) injections, widely used to treat unstable angina (UA)
This study aimed to identify the potential targets and pathways of DHI as a therapy against UA using the network pharmacology approach, and systematically elucidate the mechanism of DHI in the treatment of UA
We identified the dense regions of DHI-UA protein-protein interaction (PPI) network according to the default parameters of Molecular Complex Detection (MCODE)
Summary
Danhong injection (DHI), which is one of the most well-known Traditional Chinese Medicine (TCM) injections, widely used to treat unstable angina (UA). UA, ST-segment elevation myocardial infarction (STEMI) and non–STsegment elevation myocardial infarction (NSTEMI) have been collectively described acute coronary syndromes (ACS) [3]. UA has clinical evidence of myocardial ischemia, the key characteristic is without significant myocardial injury [4,5,6]. Previous studies have shown that the pathogenesis of unstable angina is mainly related to platelet activation and aggregation and the inflammatory response-induced decline in the stability of atherosclerotic plaque [7, 8]. UA is usually controlled by antiplatelet medications, antithrombin, antianginal and thrombolytic therapy in clinic [3, 9]. As a thiophene pyridine derivative, clopidogrel can block the activation of P2Y12 adenosine diphosphate (ADP) receptor on platelets and effectively diminish
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