Abstract
Results The changes of FT-IR spectraat 1743 cmresulted from hyperoxidation of lipids due to oxidative stress. The characteristic bands at the spectral regions 1200-900 cm and 700-400 cmshowed the formation of low crystallinity biological hydroxyapatite (Ca10(PO4)6(OH)2) and calcium monophosphate (CaHPO4) salts. The results were confirmed using SEM-EDAX and XRD analysis. The observed cross-linking bonds between collagen and elastin were the principal sites for calcium deposition and progression. The findings confirmed the hypothesis that hydroxyapatite is formed predominantly due to ATP cycle, where the release of phosphate anions take place in ischemic pathways.
Highlights
The calcification ofaortic valves is a common diseaseand valve replacement is the only established treatment
We use infrared (FT-IR) spectroscopyto investigate and characterize the mineral deposits in order to understand the mechanism of aortic valve calcification and stenosis
The characteristic bands at the spectral regions 1200-900 cm-1 and 700-400 cm-1showed the formation of low crystallinity biological hydroxyapatite (Ca10(PO4)6(OH)2) and calcium monophosphate (CaHPO4) salts
Summary
Investigating the mechanism of aortic valve stenosis: the role of magnesium salts. V Dritsa, K Pissaridi, J Anastassopoulou, E Koutoulakis, I Mamarelis, Chr Kotoulas4*. From 23rd World Congress of the World Society of Cardio-Thoracic Surgeons Split, Croatia. From 23rd World Congress of the World Society of Cardio-Thoracic Surgeons Split, Croatia. 12-15 September 2013
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