Abstract
Objective: Ovarian cancer exists within a complex tumor microenvironment critical to supporting tumor survival, growth, and metastasis. Within the tumor microenvironment, tumor-stromal-immune cell interactions create an immunosuppressive environment and facilitate treatment resistance. Antitumor T cells are associated with improved patient survival, while immunosuppressive cells T regulatory cells (Tregs) are associated with decreased survival. Previous data demonstrate that Tregs within ovarian cancers have increased neuropilin-1 (NRP-1), a cell surface protein that enhances Treg function and stability.
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