Investigating The Expression of ER, PR, And Ki-67 In Different Grades of Meningioma

Abstract

Introduction: Tumor grade is one of the significant factors in determining the prognosis of meningioma. Ki-67 is a marker expressed in the active phase of the cell cycle and indicates cell division and can be used as an auxiliary tool in determining the grade of meningioma. Steroid hormones are one of the factors that are effective in the pathogenesis of meningioma. This study evaluates the expression level of ER, PR, and ki-67 markers in different grades of meningioma.
 Materials and Methods: In a descriptive study, slides, and paraffin blocks of 80 meningioma patients who underwent surgery over 10 years at Besat Hospital, Hamedan, were extracted from the patient’s medical records and were evaluated in terms of the expression of ER markers, PR and ki-67 after immunohistochemical staining. Results: In meningioma grades 1, 2, and 3, mean PR expression was 17.33, 11.66, and zero (P=0.033), respectively, and mean Ki-67 expression was 0.67, 5.22, and 10.50, respectively ( P<0.001), and mean ER expression was zero in all three grades. There was an inverse and significant correlation between tumor grade and PR rate (p=0.04, r=-0.21). Conclusion: ki-67 expression can be used as an auxiliary method in meningioma grading, and more PR positivity indicates lower grades, and thus, better tumor prognosis.