INVESTIGATING THE EFFECTS OF PAUSINYSTALIA YOHIMBE AQUEOUS LEAVES EXTRACT ON PARAMETERS FOR REPRODUCTIVE PERFORMANCE IN EXPERIMENTAL RATS

Abstract

ABSTRACT BACKGROUND: Herbal plants and herbal preparations are widely used as immunomodulatory medicines that helps in improving reproductive health in humankind, and they are globally used and have rapidly grown in economic developmental importance. OBJECTIVE: The study was conducted to investigate the effects of the aqueous extract of P. yohimbe leaves on sexual reproductive performance in Wistar rats. The primary outcome of the study is the reproductive performance sexual rate. METHODS: The experimental study was carried out on albino rats of the Wistar strain, weighing between 150 and 200g sexually naive. The animals were raised in polyethylene cages and divided into four groups, which received a saline solution (control group), 2, 5, and 10 mL/kg of the aqueous extract of P. yohimbe leaves for fourteen days orally. The sexual behavior test was performed according to three types of crossing. RESULTS: The results of the treated groups showed a significant increase in mating frequency compared to the control group. Overall, the results showed that P. yohimbe significantly affects sexual behavior. The aqueous extract of P. yohimbe leaves increased sexual behaviour and orientation activity performance recorded in the treated rats. CONCLUSION AND RECOMMENDATION: The enhanced reproductive performance appetitive detected in the study, justify the indigenous use of the herbal plant in reproductive medicine and could be a precursor in the synthesis of useful drugs. However, based on the current findings, we recommend that careful administration be considered as a better option justifying human circumstances for patient with advanced mankind age in low dosage resource settings, as it achieves a better reproductive performance rate at a lower dose dependent increase.