Abstract
Investigating the Effects of Formetanate Hydrochloride on Human Hemoglobin by Spectroscopic Analysis and Molecular Docking Modeling
Highlights
Hemoglobin (Hb) plays a crucial role in the vascular system of human beings as a carrier of oxygen
Formetanate hydrochloride [m(((dimethylamino)methylene)amino)phenylmethylcarbamate hydrochloride] is an effective insecticide and acaricide which is frequently used in citrus gardens
We observed that increasing the concentration of formetanate hydrochloride to the Hb solution introduced a significant red shown in figures 5 and 6, binding of shift in intrinsic fluorescence intensity of free protein
Summary
Hemoglobin (Hb) plays a crucial role in the vascular system of human beings as a carrier of oxygen. According to its atomic structure, hemoglobin is a tetrameric protein composed of two identical α and two identical β chains each consisting of 141 and 146 amino acid residues, respectively that are held together by non-covalent bonds. They share a common tertiary structure that makes the globin part of each subunit to form a hydrophobic pocket that envelopes the heme prosthetic group. We investigate effects of formetanate hydrochloride on human hemoglobin using spectroscopic analysis and molecular docking modeling
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