Investigating the Effects of Fentanyl and Nitroglycerin on Hemodynamic Changes During Laryngoscopy: A Randomized Trial

Abstract

Background: Laryngoscopy is the required procedures in general anesthesia that can cause cardiovascular disorders for the patient. Various pharmacological methods are used to reduce unwanted laryngoscopy responses. Objectives: The present study aimed to compare the effects of fentanyl and nitroglycerin spray on hemodynamic responses during laryngoscopy. Methods: In a clinical trial study, 40 patients were divided into two groups. In one group of patients, intravenous fentanyl (2 µg/kg) was given and in the other group, 2 puffs sublingually nitroglycerin spray was given in addition to receiving fentanyl. Hemodynamic variables were measured at one minute before and after laryngoscopy. The data was analyzed using SPSS version 19 software. Results: The study data showed that there is no statistically significant difference between the study groups in terms of demographics. Systolic and diastolic blood pressure, as well as heart rate decreased significantly in the group of receiving simultaneous fentanyl and nitroglycerin in comparison to the group receiving fentanyl alone. Conclusions: The results of our study showed that the administration of nitroglycerin spray with fentanyl more weakened the cardiovascular responses induced by laryngoscopy.