Investigating the effect of some fluoroquinolones on blood glucose and insulin levels in STZ-induced diabetic wistar rats

Abstract

Fluoroquinolone antibiotics may cause acute disorders in blood glucose levels, this side effect is worthwhile, especially in diabetic patients, this study aimed to investigate the effect of each of two fluoroquinolones, moxifloxacin and levofloxacin, on blood glucose levels in STZ-induced diabetic wistar rats after induction of a type 2-like diabetes, and ensuring the stability of the diabetic condition, as well as waiting for aging (4 months). Experimental animals were divided into four groups: group 1; diabetic animals were treated with moxifloxacin (n=15), group 2; diabetic animals were treated with levofloxacin (n=15), group 3; diabetic control animals (n=15), and group 4; non-diabetic control animals (n=6), insulin levels, body weights, and blood glucose levels were compared at different times for a period of 14 days during the treatment with fluoroquinolones. Fluoroquinolones reduced blood glucose levels, this effect was greater with levofloxacin than moxifloxacin, accompanied with high insulin levels with levofloxacin more than moxifloxacin. There were no statistically significant differences in body weights after treating with fluoroquinolones, in conclusion: there are dissimilarity in the effect of moxifloxacin and levofloxacin on blood glucose and Insulin levels in type-2 diabetes, inspite of the importance of these compounds in the treatment of resistant infections on other antibiotics, it is necessary to exercise caution when using these compounds in diabetic patients through the precautional monitoring of blood glucose levels.