Investigating the effect of herbal antioxidants on the process of colon cancer treatment: A systematic review

Naser Mohammad Gholi Mezerji,Mostafa Eghbalian,Abbas Moghimbeigi,Mahmoud Rafieian Kopaei,Miriam Dwek

doi:10.1080/2331205x.2020.1735682

Abstract

AbstractThis study is asystematic review conducted in July, 2017. Related studies were searched in scientific databases of Biomed central, PubMed, Sciencedirect, Science of the Web, and Scopus acco...

Highlights

Colorectal cancer is the most common cancer of the digestive tract and the fourth cause of cancer death in the world (Iacopetta, 2002)
The following keywords were used for the combined search strategy: “Colorectal Neoplasm” OR “Colorectal Neoplasms” OR “Colorectal cancer” AND Prevent* OR prevention OR diagnosis* OR screening OR therapy* OR therapeutics AND garcinia* OR GIE OR “garciniaindica” OR antioxidant OR “herbal antioxidant” OR “antioxidant” OR “herbal antioxidant” OR “anti-oxidant” OR carotenoid* OR flavonoid OR polyphenelie* OR phenylpropanoid OR anthocyanin OR tannin OR lignin OR “vitamin C” OR “vitamin C” OR “vitamin-C” OR “scorbic acid” OR “vitamin E” OR “tocopherol” OR “catechins” OR polyphenole* OR “phenolic acid” OR vitamin* OR phenol* OR “nonflavonoid phenolic” OR “organic antioxidant” AND effect* OR control* OR evaluation* OR program* AND “randomized controlled trial” OR “cluster-randomized controlled trial” OR
- The percentage of subjects remaining free of polyps estimated from Kaplan-Meier survival curves was similar for those assigned to vitamin supplementation and for those assigned to placebo, and the log rank test revealed no significant difference between the groups (P > 0.30)

Summary

Introduction

Colorectal cancer is the most common cancer of the digestive tract and the fourth cause of cancer death in the world (Iacopetta, 2002). This cancer is divided into two types: hereditary and nonhereditary. More than 1,200,000 people are diagnosed with this cancer in the world and over 600,000 people die, and this number is increasing (Ferlay etal., 2015). This cancer is ahighly heterogeneous disease caused by genetic and environmental factors and it progresses through the gradual accumulation of genetic and environmental changes leading to the transformation of normal mucosal cells into cancer cells (Binefa etal., 2014).

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Conclusion