Investigating the effect of eye drops based on iodine nanoparticles in the treatment of rabbit eye endophthalmitis

Abstract

ABSTRACT purpose Several studies have been conducted to find the best treatment for endophthalmitis. The present study investigates the effect of eye drops based on iodine nanoparticles in treating rabbit endophthalmitis. Methods 15 New Zealand rabbits infected with Staphylococcus aureus (ATCC 25,923) endophthalmitis were randomly divided into three groups of five. (I, II, and III). Group I was used as the control group (without treatment). The second group received an iodine solution (1.25%) without a nanoparticle structure (betadine). The third group received iodine eye drops with nanoparticle structure. Microbial counts and disease severity scores were measured on the first, second, fifth, and fourteenth days. Results In terms of microbial load, there was a significant difference between the two groups receiving iodine based on nanoparticles and betadine and the untreated group. The use of iodine nanoparticles led to a further decrease in bacterial load. Betadine and untreated groups showed worsening of the disease in rabbits with endophthalmitis, but the severity of the disease decreased in the nano-iodine group. There was a significant difference between the untreated and nano-iodine groups (p = 0.008). Conclusions Using eye drops based on iodine nanoparticles effectively reduces the microbial load and disease severity in rabbits with endophthalmitis.