Abstract
Traumatic brain injuries (TBIs) are a major health risk that increases with age. Natural brain aging results in cerebral atrophy and the enlargement of the ventricular regions. The objective of this study is to investigate the effect of cerebral atrophy on brain biomechanics with subject-specific models to determine the risk of traumatic brain injury (TBI). Utilizing subjects from a longitudinal study of aging in healthy volunteers, we created subject-specific brain models of a small cohort with progressive age-related cerebral atrophy. We then simulate concussive loading conditions to study changes in brain deformation, a correlate to risk of TBI. The results display differing trends with increasing ventricle volume, with some subjects exhibiting increases and others showing decreasing strain. Additional subject simulations are needed to clarify these the causes of these trends.
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