Abstract
Use of statins reduces the risk of cardiovascular diseases, however, in some studies, contradicting results about statins especially atorvastatin with the risk of diabetes have been reported. The purpose of the present study, was to investigate the effect of atorvastatin drug on HbA1c in patients with myocardial infarction hospitalized in Farshchian Hospital, Hamadan. 60 patients hospitalized in CCU, who were diagnosed with one type of infarction were included in this clinical trial performed as a before-after study. Demographic data were collected using a questionnaire. Before the study and 6 months after the start of the study, the parameters of lipid profile, HbA1c and GFR were measured. Atorvastatin with a dose of 80mg was given to the patients from the beginning of the study for 6 months. The results were analyzed using SPSS. The average age of the male and female patients was 63.83 and 61.11, respectively, which had an insignificant difference. 42 patients (70%) were male and the rest of them were female. Lipid profile results at the end of the study showed improved averages for the parameters, all of which were statistically significant compared to their values at the start of the study. The mean HbA1c increased from 6.19 to 6.43 (P=0.001), the mean fasting blood sugar increased from 103.66 to 110.51 (P=0.001), and the average glomerular filtration rate (GFR) decreased from 69.84 from the start of the study to 67.43 which was statistically significant (P=0.002). Systolic and diastolic blood pressure at the end of the study decreased compared to the start of the study where in systolic blood pressure, this decrease was significant (p=0.003). Based on the results of this study, although the use of atorvastatin reduces lipids, it may create the risk of hyperglycemia in these patients. However, a certain conclusion requires further studies.
Highlights
Atorvastatin is from the category of statin drugs and an inhibitor of HMG-CoA enzyme of Hepatic Reductase which through the inhibition of cholesterol synthesis in the liver, significantly decreases the blood LDL level and prevents the progression of its complications, especially cardiovascular problems [1]
The data of this study was analyzed using the SPSS software and appropriate statistical tests at the significance level of 0.05. In this clinical trial performed as a before-after study, 60 patients with myocardial infarction who met the study inclusion criteria were included into the study
The results of some past studies indicate an increase in blood sugar among people consuming statins atorvastatin, but few statins have focused on the effect of statins on HbA1c [12, 18, 21, 20]
Summary
Atorvastatin is from the category of statin drugs and an inhibitor of HMG-CoA enzyme of Hepatic Reductase which through the inhibition of cholesterol synthesis in the liver, significantly decreases the blood LDL level and prevents the progression of its complications, especially cardiovascular problems [1]. Atorvastatin is used for people with hyperlipidemia or any type of atherosclerotic cardiovascular diseases because in addition to its lowering effect on blood lipids, it has good digestive tolerance and is rapidly absorbed from the digestive tract [2]. This drug is used for primary prevention of heart attack and stroke in patients with risk factors such as history of hypertension, smoking, high LDL and low HDL and positive family history of coronary artery disease and for secondary prevention in patients with myocardial infarction and individuals with unstable angina [3].
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