Abstract
The effect of aspirin on the toxicology of mercury was investigated by using fish. The variations between blood parameters of the fish, which were made exposed directly to mercury solutions prepared at certain concentrations (500 μg/L, 250 μg/L, 125 μg/L, 62.5 μg/L, and 31.25 μg/L), and blood parameters of the fish, which were made exposed to mercury at the same concentrations after they had been interacting with aspirin, were investigated. At the end of the study, increases in blood parameters were observed depending on the increases in mercury concentration. Statistically significant variations were observed in blood parameters of the fish, which were made exposed to mercury at the same concentrations after they had been interacting with aspirin, compared to blood parameters of the fish, which were made exposed directly to mercury (). It was found that aspirin has caused significant increases in especially the levels of serum aspartate aminotransferase and alanine aminotranspherase and significant decreases in cortisol and glucose levels among to blood parameters. It was concluded that aspirin alters the toxic effect of mercury.
Highlights
Aspirin is the popular name of a salicylate ester of acetic acid
Hilmy et al, (1985) [38] determined that serum AST and ALT levels increased under metallic effect at the beginning in Cyprinus carpio made exposed to effect of cadmium at different concentrations for 30 days and they decreased upon extension of exposure time
It was reported in some studies that increases were observed in plasma cortisol, glucose and lactate levels in different fish species exposed to stressors like heavy metals [39,40,41,42,43]
Summary
Aspirin is the popular name of a salicylate ester of acetic acid. Aspirin (acetyl salicylic acid) is an anti-inflammatory medicine, which has been in the use prevalently since 1899 for rheumatic diseases because it is very effective and inexpensive. Mercury may deposit in Journal of Ecosystems plants and animals It may cause damage in the central nervous system in case of intake by the human body. It is very important to determine variations especially in blood parameters of aquatic organisms under the effect of pollutants in metabolic and physiological events because they indicate the pollution level in that environment [19]. They may act as a chelate producer, which can collect certain metals in the body [23] This indicates a need for a study on whether or not aspirin causes different effects on organisms containing heavy metals. This study was conducted to investigate how much aspirin influences toxic effects of Mercury, which is one of the most toxic heavy metals, by using certain blood parameters of fish
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