Investigating the effect of aerobic exercise on the neuropathy symptoms caused by chemotherapy

Abstract

Introduction: Currently, there is no effective method to prevent CIPN; and if aerobic exercise combined with drug treatment is more effective than drug treatment alone, the side effects of the drug can be prevented to an acceptable extent by reducing the dose of the relevant drug. Therefore, in the following study, we tried to investigate and compare the effectiveness of two methods of aerobic exercise and drug treatment on the improvement of neuropathy symptoms caused by chemotherapy. Research materials and methods: In this clinical trial study, the first group of patients received duloxetine (Luxta, Obidi company) at a dose of 30 mg for 6 weeks. The second group received duloxetine at a dose of 30 mg along with aerobic exercise for 6 weeks. At the end of the intervention period, all patients were re-evaluated with EMGMCV of both lower limbs. The study data was analyzed using SPSS version 24 software. Findings: Two groups of cases (50 people) with an average age of 55.56 ± 4.21 years and controls (50 people) with an average age of 53.76 ± 4.57 years participated in this study. The results of EMGMCV improved significantly in both groups after the intervention, but the two groups did not show a statistically significant difference after the intervention (P<0.05). Conclusion: Based on the results of the studies and considering that aerobic exercise therapy is simple and available, since there has been no study related to the determination of the effect of combined aerobic exercise that can determine the best and most effective exercise volume affecting neuropathy. And since the existing researches are mostly focused on the effects of exercise on improving performance and neuro-muscular indicators, more clinical studies are needed in this field.