Investigating the common clinical and histopathological features in dysfunctional uterine bleeding

Abstract

Background: Dysfunctional uterine bleeding (DUB) is a diagnosis of exclusion and accounts for about one-third of all cases of abnormal uterine bleeding. It usually affects the extremes of age groups (menarche and perimenopause). Management is usually conservative. Aim: To check for any associations between clinical features and histological diagnosis to assist clinicians in the effective management of DUB patients. Methods: A questionnaire was used on every DUB patient undergoing endometrial biopsy. Questions interrogated were demographic history, obstetrics and gynaecological history and past medical history. Also their body mass index (BMI) was measured as well. Then checking for associations between histological diagnosis and common clinical presentation using Chi-square – Mantel-Haenszel test. Results: In young adults, those who were obese (10.3%), had diabetes (9.62%), irregular periods and polycystic ovarian syndrome (9.43%) were likely to develop simple endometrial hyperplasia. There was significant association between older women (>35 years of age) and endometrial carcinomas (p value = 0.050). There was also significant association between post-menopausal bleeding and endometrial carcinomas (p value = 0.0328). Conclusion: Therefore, these following criteria should be used for surgical evaluation of DUB patients: (1) younger women who are obese, diabetic, have polycystic ovaries, and irregular periods, (2) middle-aged and post-menopausal women. Reference1.Chary RN, Fatima A, Rani DJ. Endometrial histopathological changes associated with dysfunctional uterine bleeding. Asian Pac J Health Sci 2016; 3: 106–9.