Abstract
Investigating the biological response of human mesenchymal stem cells to titanium surfaces
Highlights
We have investigated the behaviour of a newly characterised population of haemarthrosis fluid-derived human mesenchymal stem cells (HF-hMSCs) with titanium (Ti) surfaces
In previous work we have identified a novel population of osteogenic human mesenchymal stem cells derived from haemarthrosis fluid, the intra-articular bleed that is aspirated from the joint space during the acute phase of injury [17,18]
The aim of this study is to investigate the behaviour of heamarthrosis fluid-derived human mesenchymal stem cell (HF-hMSC) in response to titanium screws that are used to fix the soft tissue graft during standard anterior cruciate ligament (ACL) reconstruction
Summary
We have investigated the behaviour of a newly characterised population of haemarthrosis fluid-derived human mesenchymal stem cells (HF-hMSCs) with titanium (Ti) surfaces. Titanium (Ti) is one of the most common metals chosen for the manufacture of these medical devices with its chemistry providing high specific strength, a low Young’s modulus of elasticity that reduces the impact of peri-implant bone resorption, a high capacity for connecting to bone and soft tissues and the formation of a titanium oxide surface layer that supports biocompatibility and resistance to corrosion [1,2,3,4,5]. Because of these properties, Ti is often regarded as a. Revision surgery as a result of graft failure occurs within approximately 20% of cases and the prolonged period of joint destabilisation risks further meniscal and chondral damage in the short term as well as increasing the incidence of chronic degenerative joint diseases such as osteoarthritis [15,16]
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