Investigating the Association between rs712829 Polymorphism of EGFR Gene with Lung Cancer as a Predictive Marker in Iranian Population

Abstract

Background and Objectives Lung cancer is the leading cause of cancer death globally. The epidermal growth factor receptor (EGFR) plays an important role in cell proliferation and signaling. In this study, we examined the association between EGFR (rs712829) gene polymorphism and lung cancer risk among the Iranian population. Subjects and Methods A total of 100 patients with primary lung cancer and 100 matched healthy controls were recruited into this study. EGFR rs712829 single nucleotide polymorphism (SNP) were genotyped by PCR-RFLP techniques for this association with lung cancer risk. Results A significant association was observed between the GG genotype (P= 0.039, OR= 5.500, CI=95%; 1.710- 11.921) and also G (P= 0.001, OR= 2.967, CI=95%; 1.557- 5.691) allele of rs712829 SNP with lung cancer risk, this was while the TT genotype and T allele of this polymorphism showed a protective role against risk of lung cancer. Conclusion In conclusion, EGFR rs712829 was associated with a risk of lung cancer among Iranians. More studies in other Iranian populations are required to confirm the present findings.