Investigating the Association Between Metabolic Syndrome and Adenomyosis [24B

Abstract

INTRODUCTION: Adenomyosis is characterized by endometrial tissue dispersed in the myometrium of the uterus, causing heavy menses and dysmenorrhea. As of today, there is no confirmed etiology, although associations with obesity have been documented. The objective of this study is to identify additional factors such as metabolic syndrome and to determine if there is an association with adenomyosis. METHODS: We performed a retrospective electronic chart review of pelvic ultrasounds and clinical charts to extract surrogate markers suggestive of metabolic syndrome such as weight, BMI, HbA1c, and serum lipid profile. RESULTS: Preliminary data analysis of 200 patient charts, with 100 patients in each of the control (CON) and adenomyosis (AM) groups, was performed. This analysis showed that there was a statistically significant difference in weight between the two groups, with the AM group having a BMI 3.62kg/m2 higher than those in the CON group. Prior pregnancy also presented as a statistically significant difference, with the AM group (85.9%) being more likely to have been previously pregnant compared to the CON group (60%). Our data did not show statistically significant differences between the two groups among the other markers of metabolic syndrome. CONCLUSION: Limitations to this study include sample size, retrospective nature of the study, and the impact of medications used to treat hypertension, hyperlipidemia, and/or diabetes on the development of adenomyosis. Additional analysis is currently being performed to exclude patients who are taking medication for comorbidities relating to metabolic syndrome in order to better understand the association between metabolic syndrome and adenomyosis.