Abstract

Stroke has become one of the leading causes of death, with ischaemic stroke as the most common type of stroke occurrence compared to haemorrhagic stroke. Chronic kidney disease(CKD), another important cause of death, shares several traditional cardiovascular riskfactors with ischaemic stroke. Therefore, it is important to examine the existence of shared risk factors in the association between CKD and ischaemic stroke. This study used a health examination database from a medical centre in Taiwan. A generalized linear regression analysis was used to determine the association between CKD and ischaemic stroke. The Maentel-Haenszel test was performed to analyse the effect of possible confounding factors on the association between CKD and ischaemic stroke. A prevalence rate study showed that more subjects with CKD suffered from ischaemic stroke than subjects without CKD. Diabetes, hypertension, hypertriglyceridemia, and hypercholesterolemia were associated with increased risks of ischaemic stroke in CKD subjects. There was an inverse association of the odds ratio of ischaemic stroke between CKD and non-CKD patients, which implied that younger subjects with CKD should be made aware of ischaemic stroke prevention.

Highlights

  • In the past four decades, stroke has become one of the top three leading causes of death in Taiwan[1]

  • Previous studies predicted an association of Chronic kidney disease (CKD) and stroke, especially ischaemic stroke[5,7], the nature of the association in the presence of shared risk factors should be further investigated

  • Risk factors of CKD and ischaemic stroke from previous studies are shown in Table 1, which includes risk factors considered in this study

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Summary

Introduction

In the past four decades, stroke has become one of the top three leading causes of death in Taiwan[1]. Chronic kidney disease (CKD) is another important cause of death. CKD and ischaemic stroke share several traditional cardiovascular risk factors[5]. Previous studies predicted an association of CKD and stroke, especially ischaemic stroke[5,7], the nature of the association in the presence of shared risk factors should be further investigated. Risk factors of CKD and ischaemic stroke from previous studies are shown, which includes risk factors considered in this study. The research investigated the association of CKD and ischaemic stroke among different age groups through a health examination database

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