Investigating the antibacterial activity of carboxymethyl cellulose films treated with novel Ag@GO decorated SiO2 nanohybrids

Abstract

Emergence of drug-resistant bacteria has raised the interest of employing antimicrobial biomaterials for acute wound treatment. This study aimed at preparing novel antibacterial CMC films containing different proportions of silica and graphene oxide/silver nanohybrids. The synthesis of high-purity SiO2 particles was performed by the reaction of neutralization of sodium silicate solution with HCl solution and characterized by XRD, FTIR, FE-SEM, EDS and ICP. Sonochemical method was utilized to fabricate Ag@GO nanohybrid. Different proportions of the synthesized SiO2 were incorporated into the Ag@GO nanohybrid via a simple precipitation method to obtain Ag@GO-SiO2 particles, which were then analyzed by XRD, FTIR, FE-SEM and EDS. Finally, the in-vitro antibacterial examination via disk diffusion and optical density methods indicated the effective antimicrobial activities of the films towards E. coli, P. aeruginosa and S. aureus. These findings expressed the ability of the obtained novel films in protecting wound from pathogenic microbial infections.