Investigating reading pathways after left putamen damage

Abstract

Event Abstract Back to Event Investigating reading pathways after left putamen damage Juliana Bagdasaryan1*, Mohamed L. Seghier2, Susan Prejawa2 and Cathy C. Price2 1 Institute of Neurology, University College London, United Kingdom 2 Wellcome Trust Centre for Neuroimaging, UCL, United Kingdom Reading can occur in different ways. Using Dynamic Causal Modelling (DCM, Friston et al., 2003), Seghier and Price (2010) found that, during reading, the left putamen and left thalamus were involved in different reading pathways, with further evidence for a third pathway that did not involve either the putamen or the thalamus. Hypothesis: Can patients still read when the left putamen is damaged? On the basis of Seghier and Price (2010), we predict that, (a) reading will become more reliant on the thalamic pathway or a third pathway; and (b) this will result in more activation in the left thalamus or other regions. Behavioral and fMRI data from 2 patients with damage to the left putamen was compared to that from 25 healthy controls. Language assessments determined their reading accuracy, fMRI determined the activated brain areas during successful reading trials. DCM will be used to determine the interaction of identified brain areas. Language assessments show that the patients can still read many words although their speech production is mildly aphasic. fMRI of reading shows that, in comparison to controls, the patients have significantly reduced activation in the left putamen with significantly increased activation in the left thalamus. In addition, both patients showed increased activation in the left supramarginal gyrus (SMG). Reading is still possible when the left putamen is damaged but becomes more reliant on the left thalamus and the left SMG. This confirms the hypothesis from Seghier and Price (2010) that the putamen and thalamus are parts of independent reading pathways. Future DCM analysis will allow to assess the connectivity between these Regions of Interest and will investigate whether the left SMG is part of the same reading pathway as the thalamus or a part of third pathway. Funding: Supported by the Wellcome Trust Centre for Neuroimaging. Keywords: fMRI, Language Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Neural Bases of Language Citation: Bagdasaryan J, Seghier ML, Prejawa S and Price CC (2011). Investigating reading pathways after left putamen damage. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00503 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Juliana Bagdasaryan, Institute of Neurology, University College London, London, United Kingdom, juliana.bagdasaryan@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Juliana Bagdasaryan Mohamed L Seghier Susan Prejawa Cathy C Price Google Juliana Bagdasaryan Mohamed L Seghier Susan Prejawa Cathy C Price Google Scholar Juliana Bagdasaryan Mohamed L Seghier Susan Prejawa Cathy C Price PubMed Juliana Bagdasaryan Mohamed L Seghier Susan Prejawa Cathy C Price Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.