Abstract
A non-invasive method of imaging laser irradiated blood vessels has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders. The CDOCT system used a 1280 nm center wavelength superluminescent diode. A 585 nm, 360 aes pulsed dye laser was used to irradiate hamster dorsal skin flap window preparations. Irradiation sites were imaged with CDOCT prior to, immediately after, and 24 hours after laser irradiation. The processed CDOCT signal provided an estimate of the blood flow velocity. An increase in the blood vessel backscattered signal was observed as blood or vessel walls were coagulated. A decrease in damaged blood vessel reflectivity occurred after twenty four hours.
Highlights
Pulsed dye lasers have been used to treat a variety of vascular disorders, including port wine stains and telangiectasias
The white circle represents the extent of the laser beam (5 mm diameter), and the white line shows the location of Color Doppler Optical Coherence Tomography (CDOCT) imaging
CDOCT magnitude and Doppler images are given in Figure 2b and 2c, respectively
Summary
Pulsed dye lasers have been used to treat a variety of vascular disorders, including port wine stains and telangiectasias. The desired effect of laser treatment is destruction of the abnormal blood vessels and sparing of the surrounding tissue. Histological analysis from biopsies has historically been used to investigate the effects of laser irradiation of blood vessels. For pulsed dye lasers (PDLs) in the 577-590 nm wavelength and hundreds of microseconds pulse duration range, commonly seen effects are agglutination and extravasation of erythrocytes, and destruction of vessel endothelium and perivascular collagen [1,2]. It is impossible to follow the response of a single vessel over a period of hours or days. Another limitation of histology is the mechanical artifacts introduced during tissue processing
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