Abstract
Distillation precipitation polymerization (DPP) of acrylic acid were studied in the presence of two different crosslinkers including N,N′‑methylenebis(acrylamide) (MBA) and ethylene glycol dimethacrylate (EGDAMA). After morphological study of the resultant particles, the best morphological sample was selected as seed for seeded emulsion polymerization (SEP). Composite particles were fabricated by SEP of 2‑(dimethylamino)ethyl methacrylate (DMAEMA) and MBA as crosslinked. Patchy particles, polyhedral core-shell particles, cauliflower-like particles, core-shell particles with porous shell, dumbbell-like particles and core-shell particles were synthesized by different strategies. The size, structure and surface morphology of synthesized particles were characterized using DLS and FE-SEM techniques. Morphology development and mechanism of shell formation such as nucleation and growth of lobes on seed particles were investigated. Finally, well-defined morphologies have been used as doxorubicin hydrochloride (DOX) anti-cancer drug carriers and DOX release kinetics has been discussed by different mathematical models.
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