Abstract

Japanese Encephalitis Virus (JEV) belongs to the viral family Flaviviridae, transmitted through competent mosquito vectors. JEV is responsible for ∼68,000 clinical cases each year; 25% result in death, while 20-30% of survivors have resultant neurological sequelae. This family includes many other deadly viruses such as Zika, Dengue, and West Nile. Studies have shown, and others theorized that flavivirusesundergo long-range 5' - 3' terminal region (TR) interactions mediated by a complementary cyclization sequence.

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