Abstract
Numerous genetic and environmental factors increase the complexity of schizophrenia. These factors have the potential to cause systemic pathophysiological changes throughout the body, including in the blood, that are long-lasting and can be identified in adulthood. Importantly, these associated factors may influence DNA methylation to mediate vulnerability for schizophrenia. We have implemented a novel approach to study DNA methylation in schizophrenia patients that uses their biological parents as controls. This reduces environmental and genetic confounders between cases and controls, thereby increasing our ability to identify DNA methylation patterns associated with schizophrenia.
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