Investigating Chronic Obstructive Pulmonary Disease (COPD) in Vietnamese Patients Using Impulse Oscillometry (IOS)

Abstract

Crucial measurement of Chronic Obstructive Pulmonary Disease (COPD) relies extensively on the use of spirometry, “gold standard” for diagnosis of COPD. Impulse oscillometry system (IOS) is a non-volitional way to access the mechanical structure of the respiratory system. The goals of our study were to find out the sensitivity and specificity of the IOS in diagnosis of COPD patients, and investigate which IOS parameters are related to severity and airflow obstruction in Vietnamese COPD patients. The study contain twenty-two COPD patients (stage 3 and 4) and Thirty-four healthy people, whole of them are greater than 40 years, were recruited in Community Health Care Center, Ho Chi Minh city, Vietnam. IOS measurements (R5, R20, X5, X20, AX, Fres and Delta R5-R20), and Spirometry (FEV1, FEV1/FVC) were performed. Pearson or Spearman correlation determined the relationships between IOS and Spirometry. Firstly, R5, X5, X20, AX, Fres & Delta R5-R20 were all significantly associated (p < 0.05) with FEV1. However, R20 were not related to FEV1. The strongest associations were observed between FEV1 and X5 (r = 0.7737), AX (r = -0.7825) and Delta R5-R20 (r = -0.7823). Secondly, X5, AX & Delta R5-R20 were significantly associated with FEV1/FVC. The strongest correlation was observed between Delta R5-R20 and FEV1/FVC with r = -0.6903. Reactance airway measurements (X5, X20, AX, Fres), peripheral airway resistance (Delta R5-R20) and total respiratory resistance (R5) are closely related to Vietnamese COPD diagnosis than central respiratory resistance (R20). The IOS measurements can be a significant value for COPD diagnosis in Vietnamese patients.