Abstract
Hepatocellular carcinoma (HCC) is among most common terminal cancer types in the world. Primary etiological factors include cirrhosis, hepatitis, aflatoxin and alcohol. The current study was conducted to determine cytosolic erythrocyte carbonic anhydrase and catalase enzyme activities and levels of some trace elements. For this purpose, 40 patients with primary and metastatic hepatic cancer and 29 healthy volunteers enrolled to the study. Catalase and carbonic anhydrase enzyme activities and serum trace element levels were measured in patient and control groups. In the current study, serum copper, magnesium, manganese and zinc levels were lower in the primary and metastatic hepatic cancer group in comparison with the control group (P
Highlights
Hepatic carcinoma is one of common solid cancers, which leads to the death of 650,000 people per year worldwide [1]
Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic carcinomas, while cholangiocellular carcinoma (CCC) accounts for 10 percent of all liver cancer cases [3,4]
There was no significant difference between the primary hepatic cancer group and the metastatic hepatic cancer group with respect to CAT level (P > 0.05)
Summary
Hepatic carcinoma is one of common solid cancers, which leads to the death of 650,000 people per year worldwide [1]. The most significant risk factor of hepatic cancer is liver cirrhosis. It accounts for 90% of hepatic carcinoma cases. Hepatic tumors are divided into three groups, includeing primary benign, primary malignant and secondary (metastatic) tumors. The ratio of primary and metastatic tumor is 1/20. Primary hepatic cancers are usually divided into two groups. If the tumor originates from hepatocytes, it is referred to as hepatocellular carcinoma (HCC), while the term is cholangiocellular carcinoma (CCC) if it is derived from intra-hepatic bile ducts. HCC accounts for 90% of primary hepatic carcinomas, while CCC accounts for 10 percent of all liver cancer cases [3,4]
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