Abstract
Systemic fungal infections have increased significantly in recent years and this is important particularly for immunocompromised patients. A series of ambruticin carboxylic acid analogues have been synthesised through semi-synthesis and tested for their antifungal activity. The results suggest that the carboxylic acid is not crucial for potency, with the tetrazole 16 analogue showing similar antifungal activity to ambruticin VS-3 4.
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