Investigating ADAMTS7 and ADAMTS12 levels in prediabetic and Type 2 diabetic patients.

Abstract

Background: This study aims to investigate the role of ADAMTS7 and ADAMTS12 on atherosclerosis and inflammation in prediabetic and diabetic patients. Patients & methods: Serum ADAMTS7 and ADAMTS12 levels were compared with the atherosclerotic and inflammatory markers in diabetic (n=65, female30.9%, mean age=53 years), prediabetic (n=55, female36.6%, mean age =49 years) and control groups (n=55, females32.5%, mean age=49 years). Serum ADAMTS levels were determined by a human enzyme-liked immunoassay. Results: In terms of ADAMTS7, there was no significant difference between diabetic, prediabetic and control groups (50.93, 44.34, 59.07, respectively; p>0.05). ADAMTS12 is lower in diabetics (p<0.05), whereas it is similar in prediabetics and controls (14.53, 20.76, 25.05, respectively; p>0.05). ADAMTS7 and ADAMTS12 levels did not differ in diabetic nephropathy, retinopathy and neuropathy (p>0.05). Conclusion: While ADAMTS12 was significantly lower in diabetics and prediabetics, ADAMTS7 and ADAMTS12 were not related to diabetic complications (nephropathy, retinopathy and neuropathy).