Abstract
To find genes associated with kidney disease, the fawn‐hooded hypertensive (FHH) rat was crossed with the normotensive, renal resistant August × Copenhagen Irish (ACI) strain. We used a genetic mapping strategy to locate five quantitative trait loci (QTLs) on the rat genome that show linkage to measures of renal impairment (Rf1–5). Following this linkage analysis, single, double and triple congenic animals were made to demonstrate the synergistic relationship between the genes within the various Rf QTLs. Double and triple congenic animals containing Rf‐1 showed more marked measures of renal impairment, which indicates that genes within these QTLs are all interacting with one another to contribute to this complex disease. We have developed Rf‐1+3+4 triple congenic animals to investigate the interaction between these three QTLs. Our current focus is to analyze candidate genes in the Rf‐3 region.National Institute of Health and the Medical College of Wisconsin
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