Abstract
Inverted papilloma is an uncommon benign epithelial tumor that typically affects the nasal cavity and originates from the lateral sinonasal wall. Inverted papilloma occurring in the middle ear is an even more rare and aggressive condition. We describe a case of a 76-year-old man who was treated for isolated sinonasal inverted papilloma and after 20 months he was found to have a recurrence in the nasal cavity with middle ear involvement and malignant changes consistent with nonkeratinizing squamous cell carcinoma arising from inverted papilloma. Several surgical procedures were required to remove the tumor along with radiation therapy postoperatively.
Highlights
Sinonasal schneiderian papilloma is a benign neoplastic proliferation that originates from epithelial cells
We describe a case of a 76-year-old man who was treated for isolated sinonasal inverted papilloma and after 20 months he was found to have a recurrence in the nasal cavity with middle ear involvement and malignant changes consistent with nonkeratinizing squamous cell carcinoma arising from inverted papilloma
Categories: Otolaryngology, Oncology Keywords: inverted papilloma, squamous cell carcinoma, nasal mass, middle ear Sinonasal schneiderian papilloma is a benign neoplastic proliferation that originates from epithelial cells
Summary
Sinonasal schneiderian papilloma is a benign neoplastic proliferation that originates from epithelial cells. We have reviewed the literature from 1987 to 2019 and to the best of our knowledge, there are only 13 reported cases of primary sinonasal inverted papilloma with middle ear involvement in the English literature [3,4,5,6,7,8,9,10,11,12,13,14] The majority of these cases show evidence of malignant transformation. All tissue biopsies from the left mastoid, middle ear, and Eustachian tube showed invasive nonkeratinizing squamous cell carcinoma arising from inverted papilloma with malignant transformation. The patient received a total dose of 66 Gy of radiation to the left ear and completed the course of treatment over seven weeks
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